sequence with maxspan=1m
 [process where host.os.type == "windows" and event.action == "start" and
    process.name : "msiexec.exe" and process.args : "/V"] by process.entity_id
 [network where host.os.type == "windows" and process.name : "msiexec.exe" and
    event.action == "connection_attempted"] by process.entity_id
 [process where host.os.type == "windows" and event.action == "start" and
  process.parent.name : "msiexec.exe" and user.id : ("S-1-5-21-*", "S-1-5-12-1-*") and
  not process.executable : ("?:\\Windows\\SysWOW64\\msiexec.exe",
                            "?:\\Windows\\System32\\msiexec.exe",
                            "?:\\Windows\\System32\\srtasks.exe",
                            "?:\\Windows\\SysWOW64\\srtasks.exe",
                            "?:\\Windows\\System32\\taskkill.exe",
                            "?:\\Windows\\Installer\\MSI*.tmp",
                            "?:\\Program Files\\*.exe",
                            "?:\\Program Files (x86)\\*.exe",
                            "?:\\Windows\\System32\\ie4uinit.exe",
                            "?:\\Windows\\SysWOW64\\ie4uinit.exe",
                            "?:\\Windows\\System32\\sc.exe",
                            "?:\\Windows\\system32\\Wbem\\mofcomp.exe",
                            "?:\\Windows\\twain_32\\fjscan32\\SOP\\crtdmprc.exe",
                            "?:\\Windows\\SysWOW64\\taskkill.exe",
                            "?:\\Windows\\SysWOW64\\schtasks.exe",
                            "?:\\Windows\\system32\\schtasks.exe",
                            "?:\\Windows\\System32\\sdbinst.exe") and
  not (process.code_signature.subject_name == "Citrix Systems, Inc." and process.code_signature.trusted == true) and
  not (process.name : ("regsvr32.exe", "powershell.exe", "rundll32.exe", "wscript.exe") and
       process.Ext.token.integrity_level_name == "high" and
       process.args : ("?:\\Program Files\\*", "?:\\Program Files (x86)\\*")) and
  not (process.executable : ("?:\\Program Files\\*.exe", "?:\\Program Files (x86)\\*.exe") and process.code_signature.trusted == true) and
  not (process.name : "rundll32.exe" and process.args : "printui.dll,PrintUIEntry")
  ] by process.parent.entity_id
Install detection rules in Elastic Security
Detect Potential Remote File Execution via MSIEXEC in the Elastic Security detection engine by installing this rule into your Elastic Stack.
To setup this rule, check out the installation guide for Prebuilt Security Detection Rules(opens in a new tab or window).