event.category:process and host.os.type:windows and
  powershell.file.script_block_text : (
   (VirtualAlloc or VirtualAllocEx or VirtualProtect or LdrLoadDll or LoadLibrary or LoadLibraryA or
      LoadLibraryEx or GetProcAddress or OpenProcess or OpenProcessToken or AdjustTokenPrivileges) and
   (WriteProcessMemory or CreateRemoteThread or NtCreateThreadEx or CreateThread or QueueUserAPC or
      SuspendThread or ResumeThread or GetDelegateForFunctionPointer)
  ) and not 
  file.directory: (
    "C:\ProgramData\Microsoft\Windows Defender Advanced Threat Protection\SenseCM" or
    "C:\ProgramData\Microsoft\Windows Defender Advanced Threat Protection\Downloads"
  )